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Archiver > GENEALOGY-DNA > 2007-02 > 1170708783


From: Vincent Vizachero <>
Subject: Re: [DNA] DYS390m ?
Date: Mon, 5 Feb 2007 15:53:03 -0500
References: <001001c74945$1daac390$647ba8c0@thinkerone>
In-Reply-To: <001001c74945$1daac390$647ba8c0@thinkerone>


On Feb 5, 2007, at 11:45 AM, Robert Tarín wrote:

> They further state that the value of the four
> DYS390 segments has been neglected, probably because of
> ascertainment bias:
> in Whites, all segments but DYS390n are invariant. Maybe the
> various testing
> companies should make note of this and start segmenting these marker
> results. It could be very useful for analyzing population differences.
> Hopefully they are reading this.

It should be noted that this research is fairly old (at least six
years), so anyone who wanted to use this information has had a good
opportunity already.

For most genealogical purposes, sequencing DYS390 would offer very
little benefit since the rate of mutation ex DYS390.2 is very low.
In most cases, simply testing more STRs would accomplish a similar
goal with lower cost and greater comparability. For the study of
population structure, however, it could be useful if a systematic
sequencing of haplogroups was undertaken.

From a practical standpoint, the most interesting cases are the ones
with multi-repeat deletions at DYS390.1 or the complete deletion of
DYS390.3 and those cases almost always result in DYS390<21. Outside
of haplogroup E3a, such low values of DYS390 are exceedingly rare.


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