GENEALOGY-DNA-L Archives

From: Rebekah <>
Subject: [DNA] [Fwd: Variation of Human Mitochondrial DNA: Distribution ofHot Spots in Hypervariable Segment I of the Major Noncoding Region]
Date: Tue, 13 Mar 2007 22:25:09 -0500

repost

-------- Original Message --------
Subject: Variation of Human Mitochondrial DNA: Distribution of Hot
Spots in Hypervariable Segment I of the Major Noncoding Region
Date: Mon, 12 Mar 2007 11:23:18 -0500
From: Rebekah <>
To:



Variation of Human Mitochondrial DNA: Distribution of Hot Spots in
Hypervariable Segment I of the Major Noncoding Region
Journal Russian Journal of Genetics
Publisher MAIK Nauka/Interperiodica distributed exclusively by Springer
Science+Business Media LLC .
ISSN 1022-7954 (Print) 1608-3369 (Online)
Subject Biomedical and Life Sciences and Russian Library of Science
Issue Volume 37, Number 7 / July, 2001
DOI 10.1023/A:1016707228425
Pages 823-832
SpringerLink Date Tuesday, November 09, 2004

B. A. Malyarchuk1 Contact Information and M. V. Derenko1 Contact Information
(1) Institute of Biological Problems of the North, Russian Academy of
Sciences, Magadan, 685000 Russia

Abstract Mitochondrial DNA (mtDNA) samples belonging to fifteen
phylogenetically related mtDNA types specific to the populations of
Europe (H, V, J, T, U, K, I, W, and X) and Northern Asia (A, C, D, G, Y,
and Z) were typed for sequence variation in hypervariable segment I
(HVSI). The approach used allowed to distinguish several hypervariable
sites at nucleotide positions 16093, 16129, 16189, 16311, and 16362.
Identical mutations at these sites were found in 10–11 out of 15 mtDNA
groups examined. Positions 16126, 16172, 16192, 16256, 16261, 16291,
16293, and 16298 appeared to be less variable, since parallel mutations
at these sites were found in 6–8 European and Asian mtDNA groups. The
examples of the effects of mutations in hypervariable positions at the
major noncoding mtDNA region on the frequency of reverse mutations in
other mtDNA regions are presented. It was shown that such effects of
nucleotide context on the mutation rate could be observed in
phylogenetic mtDNA networks such as cyclic structures like rhombs and
cubes. Analogous structures in the networks could be seen also in the
case of the appearance of recombinant mtDNA types resulted from
homologous recombination between mtDNA molecules in heteroplasmic
mixture. The problem of the effect of polynucleotide context on the
intensity of mtDNA mutagenesis is discussed. Recombination processes
along with site-directed mutagenesis caused by action of genetic factors
(of nuclear genome) and/or of the environment are considered as possible
mechanisms of mitochondrial genome evolution.

Notes:
Fascinating! :-| Please don't use "intensity of mtDNA mutagenesis" at a
cocktail party.

--
Regards,
Rebekah


"And they wonder why the maples
Can't be happy in their shade." Trees (Neil Peart from Rush)

This thread:

• [DNA] [Fwd: Re: DYF 371x Result -- A Sort of Summary with questionsandcomments.] by Rebekah <>
  • [DNA] [Fwd: Mitochondrial DNA Variation in Russian Populations ofKrasnodar Krai, Belgorod, and Nizhni Novgorod Oblast] by Rebekah <>
    • Re: [DNA] [Fwd: Mitochondrial DNA Variation in Russian Populationsof Krasnodar Krai, Belgorod, and Nizhni Novgorod Oblast] by "R. & G. Stevens" <>
  • [DNA] [Fwd: The T4336C Variant Is a Marker of MitochondrialSubhaplogroup H1, a Common Component of the Russian and German Gene Pools] by Rebekah <>
  • [DNA] [Fwd: Differentiation and Genetic Position of Slavs amongEurasian Ethnic Groups as Inferred from Variation in Mitochondrial DNA] by Rebekah <>

  • [DNA] [Fwd: Variation of Human Mitochondrial DNA: Distribution ofHot Spots in Hypervariable Segment I of the Major Noncoding Region] by Rebekah <>