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Archiver > GENEALOGY-DNA > 2007-05 > 1179089838


From: "Gareth Henson" <>
Subject: Re: [DNA] Multicopy markers in population studies
Date: Sun, 13 May 2007 21:57:18 +0100
References: <000001c7942c$27b28030$4101a8c0@BigMem2>


I second John M's "maybe". Both DYS464X and TaqI 49a,f tests produce
distinctive patterns for R1b1c and as both tests relate to the (usually) 4
copy "red" sections right at the heart of the P1 & P2 palindromes some
connection or causal link seems a reasonable hypothesis.

There still doesn't seem to be any clear understanding in published papers
of what it is that generates the ht15/35 distinction. The HUGO reference
sequence doesn't seem to relate to either which is odd since it is supposed
to be from a R1b1c individual.
My current feeling is that RecLOH plays a significant part in the TaqI 49a,f
variances and I believe it is logically possible for one or both of the ht
15 and 35 groups to be paraphyletic. There is very little data to resolve
this as the most STRs available for TaqI 49a,f tested samples are in the
Cinnioglu paper. I agree that the members of the Italian project may be the
best opportunity available for extended haplotypes for "Eastern" R1b1c (even
though relying on just 2 STRs to identify them is far from ideal).

Gareth



----- Original Message -----
From: "John McEwan" <>
To: <>
Sent: Saturday, May 12, 2007 1:26 AM
Subject: Re: [DNA] Multicopy markers in population studies


> John German asked
> ......
> Do you foresee any clues to ht35 vs ht15 in the palindromic markers?
> ......
>
> I support Vince's previous recommendation about testing palindromic
> markers in R1 subclades especially 464x and DYF399x for a variety of
> reasons, and the short answer to John's query is ....maybe.....
>
> Gareth Henson is the expert, but the patterns of RecLOH that have
> occurred in R1b in the DYS464 region, may have influenced the banding
> pattern detected by Taq p49a,f. This is because Taq p49a,f queries the
> properties of the same multicopy region.
>
> Vince's more recent post of DYS393 DYS461 12 11 combo from Cinnioglu et
> al. 2004 actually infers this hypothesis can now be examined with a
> degree of precision.
>
> Cheers
>
> John McEwan


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