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Archiver > GENEALOGY-DNA > 2007-06 > 1180896767


From: valery <>
Subject: Re: [DNA] PubMed abstract: mtDNA in Franch
Date: Sun, 03 Jun 2007 18:52:52 +0000
References: <cdd.12ed7c3f.3393f43a@aol.com>
In-Reply-To: <cdd.12ed7c3f.3393f43a@aol.com> (from DNACousins@aol.com on SunJun 3 14:38:50 2007)


Does anyone have a direct link to the online paper/supplement? All I've
found is an abstract:


http://www.informaworld.com/smpp/content~content=a770384809






On 03/06/07 14:38:50, wrote:
> Ann Hum Biol. 2007 Jan-Feb;34(1):68-79.
>
> An mtDNA perspective of french genetic variation.
>
> Richard C, Pennarun E, Kivisild T, Tambets K, Tolk HV, Metspalu E,
> Reidla M,
> Chevalier S, Giraudet S, Lauc LB, Pericić M, Rudan P, Claustres M,
> Journel H,
> Dorval I, Müller C, Villems R, Chaventré A, Moisan JP.
>
> Laboratoire d'Etude du Polymorphisme de l'ADN, Faculté de Médecine,
> Nantes,
> France.
>
> BACKGROUND: The French has been insufficiently characterized so far
> for
> mitochondrial DNA (mtDNA) diversity. AIMS: The study aimed to enhance
> the
> information available for the French mtDNA pool and to explore the
> potential
> microgeographical differentiation of two French regions selected for
> their linguistic
> and historical idiosyncrasies. SUBJECTS AND METHODS: A total of 868
> samples from
> 12 different locations in France were collected. They were sequenced
> for the
> hypervariable segment I (HVS-I) and typed for haplogroup defining
> markers from
> the coding region either by restriction fragment length polymorphism
> (RFLP)
> or by a new protocol based on the 5' nuclease allelic discrimination.
> The mtDNA
> gene pools of French Basques and Bretons were compared in terms of
> frequency
> and composition with relevant neighbouring populations. RESULTS: The
> French
> Basques' mtDNA pool shares some common features with that of the
> Spanish
> Basques, such as the high frequency of haplogroup H. However, the
> French Basques
> exhibit a number of distinct features, most notably expressed in the
> prevalence of
> haplogroups linked with the Neolithic diffusion in Europe. In
> Brittany,
> Finistère shows closer affinities with Britain and Scandinavia than
> the two other
> departments of Brittany. CONCLUSION: The mtDNA haplogroup composition
> of the
> French does not differ significantly from the surrounding European
> genetic
> landscape. At a finer grain, microgeographical differentiation can be
> revealed, as
> shown for the French Basque country and for Brittany.
>
> Publication Types: Research Support, Non-U.S. Gov't
>
> PMID: 17536756 [Pubmed - in process]
>
>
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>
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