GENEALOGY-DNA-L Archives

Archiver > GENEALOGY-DNA > 2007-06 > 1181578525


From: "Joe Knapp" <>
Subject: Re: [DNA] Identifying R1b clusters
Date: Mon, 11 Jun 2007 12:15:25 -0400
References: <a81622ac0706101447u50f0d562kedfbcca0476dd8ca@mail.gmail.com><BFECJOAEEPCFBFFLLBGPKEBPDDAA.scorpion@netconnect.com.au><a81622ac0706101758g74790840v7c7e2e0e2d1eea7e@mail.gmail.com><03ea01c7ac27$8aec1c20$0200a8c0@c452380a><a81622ac0706110626l3be22a0fsd72f08834605f2e1@mail.gmail.com><043101c7ac4a$4507e090$0200a8c0@c452380a>
In-Reply-To: <043101c7ac4a$4507e090$0200a8c0@c452380a>


On 6/11/07, Earl Beaty <> wrote:
> I endorse Rebekah's suggestion to leave out the multi-copy markers. Within
> the Irish Sea cluster I see many occurrences of CDY and 464. There is
> especially a need to eliminate the two CDY markers. Chandler reports a value
> of one mutation per 28 generations for one or the other of the CDY markers.
> For the times we are talking about that is a lot of back-and-forth
> mutations.

It seems a shame to throw out information though. There's a March 2006
paper that studied different ways of ordering multi-copy markers and
found:

"Surprisingly, matrices of pairwise F-statistics or distance estimates
appear far less sensitive to order misspecification and remain
relatively unchanged under the priors considered, suggesting that
these microsatellites can be considered as useful markers for
population genetic studies using an appropriate data treatment." (P.
Balaresque, A. Sibert, E. Heyer and B. Crouau-Roy, "Unbiased
Interpretation of Haplotypes at Duplicated
Microsatellites," Annals of Human Genetics)

Still, I'll try leaving them out.

> Doing the Ysearch data would also be interesting. Ron Scott already has the
> R1b records identified.

When I did a search there were over 7,000 of them. It would be nice if
ysearch had some kind of API to get the values. All I can think of
doing is screen scrapes.

Joe

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