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From: valery <>
Subject: Re: [DNA] PubMed abstract: mtDNA in the Czech population
Date: Sat, 16 Jun 2007 18:29:05 +0000
References: <145704.16467.qm@web52102.mail.re2.yahoo.com>
In-Reply-To: <145704.16467.qm@web52102.mail.re2.yahoo.com> (fromellenlevy66@yahoo.com on Sat Jun 16 21:13:11 2007)


The data this paper goes with are in contradiction with conclusions in
the abstract. It seems that the authors have overestimated the Asian
admixture in Czechs. There are 4 such sequences in 3 samples published
to date, it's 349 individuals. This yields 1.1%. Likely, the authors
pooled several Gypsy lineages with East Asian ones, M5a is not only
Indian lineage Gypsies have. The total Czech sample still has two
unresolved M*s: one is rare and unclear while the second one is a
regular European Roma lineage. Perhaps, they have some unpublished
results to support the Asian origin of some lineages or the actual
dataset is larger than that published. The first author is one of the
most qualified specialists of the field and it's very unlikely that
there no facts to argue for the point. Furthermore, the current sample
is larger than one published by Vanecek several years ago (now Vanecek
is a coathor) and has only a limited number of Gypsy lineages (while
the previous one had 5% which was likely due to drift in the rural
population where samples were collected or just an inaccurate selection
of probands). Until something convincing is published, I'd like to
stick to the minimal value of EA which is 1.1%. It seems that Czechs
are intermediate between Western (0.5%) and Eastern Europe (1.5-2%) in
the topic of gene flow from the East Asia.



Valery


On 16/06/07 21:13:11, ellen Levy wrote:
> I have a N9a and N1c in Behar's mtDNA Ashkenazi
> samples. The haplotype for N9a is: 129, 223, 257A,
> 261, 73, 146, 150, 263.
>
> For N1c, it is: 145, 223, 265, 519, 73, 189, 195, 204,
> 207, 263.
>
> No D's, but there are five M*s: 111, 223, 235, 362,
> 519, 73, 263 (one has 199).
>
> Notable is the fact that all of these are found within
> Eastern European Ashkenazim only, suggesting admixture
> with non-Jewish Eastern Europeans or perhaps origins
> among the same Central Asian groups.
>
> Ellen Coffman
>
> --- wrote:
>
> > Hum Biol. 2006 Dec;78(6):681-96.
> >
> > Mitochondrial DNA variability in the Czech
> > population, with application to
> > the ethnic history of Slavs.
> >
> > Malyarchuk BA, Vanecek T, Perkova MA, Derenko MV,
> > Sip M.
> >
> > Institute of Biological Problems of the North,
> > Russian Academy of Sciences.
> > Portovaya str. 18, 685000 Magadan, Russia.
> >
> > Mitochondrial DNA (mtDNA) variability was studied in
> > a sample of 179
> > individuals representing the Czech population of
> > Western Bohemia. Sequencing of two
> > hypervariable segments, HVS I and HVS II, in
> > combination with screening of
> > coding-region haplogroup-specific RFLP markers
> > revealed that most Czech mtDNAs
> > belong to the common West Eurasian mitochondrial
> > haplogroups (H, pre-V HV*, J, T,
> > U, N1, W, and X). However, about 3% of Czech mtDNAs
> > encompass East Eurasian
> > lineages (A, N9a, D4, M*). A comparative analysis
> > with published data showed
> > that different Slavonic populations in Central and
> > Eastern Europe contain small
> > but marked amounts of East Eurasian mtDNAs. We
> > suggest that the presence of
> > East Eurasian mtDNA haplotypes is not an original
> > feature of the gene pool of the
> > proto-Slavs but rather may be mostly a consequence
> > of admixture with Central
> > Asian nomadic tribes, who migrated into Central and
> > Eastern Europe in the
> > early Middle Ages.
> >
> > Publication Types: Research Support, Non-U.S. Gov't
> >
> > PMID: 17564247 [Pubmed - in process]
> >
> >
> > **************************************
> >
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