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Subject: [DNA] PubMed abstract: mtDNA haplogroups and diabetes
Date: Wed, 27 Jun 2007 12:39:32 EDT
As is often the case, initial reports about an association between a
haplogroup and some condition are not confirmed in follow-up studies.
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J Med Genet. 2007 Jun;44(6):e80.
Mitochondrial DNA haplogroups and type 2 diabetes: a study of 897 cases and
1010 controls.
Chinnery PF, Mowbray C, Patel SK, Elson JL, Sampson M, Hitman GA, McCarthy
MI, Hattersley AT, Walker M.
Mitochondrial Research Group, Newcastle University, Newcastle upon Tyne, UK.
Mitochondria play a central role in the secretion of insulin by pancreatic
beta-cells, and pathogenic mutations of mitochondrial DNA (mtDNA) can cause
diabetes. The aetiology of type 2 diabetes has a strong genetic component, raising
the possibility that genetic variants of mtDNA alter the risk of developing
the disorder. Recent studies have produced conflicting results. By studying 897
UK cases of type 2 diabetes and 1010 population-matched controls, it is shown
that European mtDNA haplogroups are unlikely to play a major role in the risk
of developing the disorder.
Publication Types: Research Support, Non-U.S. Gov't
PMID: 17551080 [PubMed - indexed for MEDLINE]
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