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From:
Subject: Re: [DNA] mtdna 477c [Coble]
Date: Mon, 16 Jul 2007 05:57:03 EDT


In a message dated 7/15/2007 9:49:33 PM Pacific Daylight Time,
writes:

> I got Coble's article, but had a hard time following what markers he used.
> As nearly as I could tell, he used d16129A to indicate H3, and it doesn't,
> but I found it also in H1. He had 16263c delinieating H4, which it
> doesn't, and I found it in H1 as well. If he used markers ranging from
> different to incorrect from those used to generate the values at Y Search,
> then he is going to place things in different subclades of H.

Coble's numbering system isn't referring to H subclades. His study looked at
the coding region of the 18 most common HVR haplotypes to see if it would be
useful in sorting out matches from non-matches. H:1 is the most common H
haplotype, H:2 is the second most common, and so forth. Note the colon, which he
mentions in the "Materials and Methods" section of his paper.

This is a very important paper for understanding mtDNA diversity, and I
recommend that everyone with the tiniest bit of interest in mtDNA read it. Even
though it sounds paradoxical, it demonstrates how MOST people have RARE
haplotypes.

http://www.cstl.nist.gov/div831/strbase/pub_pres/Coble_IJLM2004.pdf

Ann Turner


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