GENEALOGY-DNA-L Archives

From: "steven perkins" <>
Subject: [DNA] Article: Elevated male European and female Africancontributions to the genomes of African American individuals.
Date: Mon, 23 Jul 2007 08:34:58 -0400

Hum Genet. 2007 Jan;120(5):713-22. Epub 2006 Sep 28.

Elevated male European and female African contributions to the
genomes of African American individuals.

Lind JM, Hutcheson-Dilks HB, Williams SM, Moore JH, Essex M,
Ruiz-Pesini E, Wallace DC, Tishkoff SA, O'Brien SJ, Smith MW.

Laboratory of Genomic Diversity, NCI-Frederick, Frederick, MD, USA.

The differential relative contribution of males and females from
Africa and Europe to individual African American genomes is relevant
to mapping genes utilizing admixture analysis. The assessment of
ancestral population contributions to the four types of genomic DNA
(autosomes, X and Y chromosomes, and mitochondrial) with their
differing modes of inheritance is most easily addressed in males. A
thorough evaluation of 93 African American males for 2,018 autosomal
single nucleotide polymorphic (SNP) markers, 121 X chromosome SNPs, 10
Y chromosome haplogroups specified by SNPs, and six haplogroup
defining mtDNA SNPs is presented. A distinct lack of correlation
observed between the X chromosome and the autosomal admixture
fractions supports separate treatment of these chromosomes in
admixture-based gene mapping applications. The European genetic
contributions were highest (and African lowest) for the Y chromosome
(28.46%), followed by the autosomes (19.99%), then the X chromosome
(12.11%), and the mtDNA (8.51%). The relative order of admixture
fractions in the genomic compartments validates previous studies that
suggested sex-biased gene flow with elevated European male and African
female contributions. There is a threefold higher European male
contribution compared with European females (Y chromosome vs. mtDNA)
to the genomes of African American individuals meaning that
admixture-based gene discovery will have the most power for the
autosomes and will be more limited for X chromosome analysis.

PMID: 17006671 [PubMed - indexed for M

--
Steven C. Perkins
http://stevencperkins.com/
Online Journal of Genetics and Genealogy
http://jgg-online.blogspot.com/
Steven C. Perkins' Genealogy Page
http://stevencperkins.com/genealogy.html

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• [DNA] Article: Elevated male European and female Africancontributions to the genomes of African American individuals. by "steven perkins" <>