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Archiver > GENEALOGY-DNA > 2007-07 > 1185339899


From: "Dora Smith" <>
Subject: Re: [DNA] Is H5a a pathological subclade?
Date: Wed, 25 Jul 2007 00:04:59 -0500
References: <c69.185ac808.33d829fe@aol.com>


I looked at some of those associations. These are mainly somatic
mutations. They take place in peoples' bodies over their lifetimes.
These aren't mutations that were inherited.

Yours,
Dora Smith
Austin, TX


----- Original Message -----
From: <>
To: <>
Sent: Tuesday, July 24, 2007 11:22 PM
Subject: [DNA] Is H5a a pathological subclade?


> _http://www.mitomap.org/rimtab3.html_
> (http://www.mitomap.org/rimtab3.html)
> lists the "Clinical Phenotypes (non-LHON)
> Associated with mtDNA rRNA and tRNA
> Mutations Reported in the Literature."
> According to this list Organized by Phenotype:
> rRNA/tRNA Mutations, T4336C in the coding
> region can be considered pathologic and is associated
> with Alzheimer's, Parkinson's Disease, deafness and migraine.
> This is considered "confirmed by multiple reports in the literature".
>
> But doesn't T4336C also help to define the subclade
> of H5a? Even without full genomic sequencing,
> it is possible to extrapolate that someone has



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