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From: Bonnie Schrack <>
Subject: [DNA] Epigenetics in latest issue of Nature
Date: Wed, 01 Aug 2007 17:10:13 -0400


Don't know that this has been posted. A brief summary that can be read
by all, of two articles in Nature that require a subscription. This page
has the links, for subscribers or those with library access:
http://www.nature.com/nature/journal/v448/n7153/edsumm/e070802-08.html


*Chromatin profiling*

Although they contain the same set of genes, different cell types in a
multicellular organism maintain very different behaviours. These cell
states are thought to be related to chromatin state — that is,
modifications to histones and other proteins that package the genome.
Single-molecule sequencing technology has now been used to construct
chromatin-state maps for mouse embryonic stem cells and two other more
developmentally advanced cell types, revealing the genome-wide
distribution of important chromatin modifications. The study provides
pointers for the use of chromatin profiling on mammalian cell
populations, including those of abnormal cells, such as cancer.


News and Views: *Genomic biology: The epigenomic era opens*

Readout of information from the genome depends on intricate regulation
of how DNA is packaged by proteins. The great endeavour to reveal how
this packaging operates pan-genomically is now under way.

Stephen B. Baylin & Kornel E. Schuebel

doi:10.1038/448548a


Article: *Genome-wide maps of chromatin state in pluripotent and
lineage-committed cells*

Tarjei S. Mikkelsen, Manching Ku, David B. Jaffe, Biju Issac, Erez
Lieberman, Georgia Giannoukos, Pablo Alvarez, William Brockman,
Tae-Kyung Kim, Richard P. Koche, William Lee, Eric Mendenhall, Aisling
O'Donovan, Aviva Presser, Carsten Russ, Xiaohui Xie, Alexander Meissner,
Marius Wernig, Rudolf Jaenisch, Chad Nusbaum, Eric S. Lander & Bradley
E. Bernstein

doi:10.1038/nature06008


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