GENEALOGY-DNA-L Archives
Archiver > GENEALOGY-DNA > 2007-08 > 1186006947
From: <>
Subject: [DNA] Relative Genetics Changes Allele Values for Five Y ChromosomeMarkers.
Date: Wed, 1 Aug 2007 16:22:33 -0600
References: <mailman.3428.1186004079.9735.genealogy-dna@rootsweb.com>
In-Reply-To: <mailman.3428.1186004079.9735.genealogy-dna@rootsweb.com>
Dear Rootsweb Genealogists
On June 18, Sorenson Genomics announced a new partnership with
Ancestry.com. All Relative Genetics' information will soon migrate to
Ancestry.com except for data of individuals who have expressly notified
us to the contrary.
As part of the data migration, we are taking the opportunity to
recalibrate some of the markers in our data set, specifically DYS 442,
DYS 452, DYS 463, GATA A10, and GATA H4. These changes are effective as
of August 1, 2007.
Sorenson Genomics adopts industry standards in reporting nomenclature as
specified by organizations, such as the National Institutes of Standards
and Technology (NIST) and the International Society of Forensic Genetics
(ISFG). While your DNA remains constant, adopting the most current
naming conventions often results in changes to your haplotype data, as
is the case with these five markers. You may be aware that there are
some discrepancies within the genetic genealogy community in the names
and methods used to identify loci and allele values. This is to be
expected in an emerging field with ever-advancing scientific methods and
discoveries. As the industry identifies and adopts new markers, the
standards bodies periodically respond by making recommendations for a
standardized naming convention for each marker. As a result, it becomes
necessary for us to adjust our reporting nomenclature to meet these
conventions.
Allele Changes
DYS442
Action taken: Increased allele value by 5 to include the following
repeat structure: (TATC)2(TGTC)3(TATC)n. Formerly, only the (TATC)n
repeat was counted.
DYS452
Action taken: Increased allele value by 19 to include the following
repeat structure (TATAC)2(TGTAC)2(TATAC)n(CATAC)1(TATAC)1(CATAC)1
(TATAC)3-4(CATAC)0-2(TATAC)0-3(CATAC)1(TATAC)3. Formerly, only the
(TATAC)n repeat was counted.
DYS463
Action taken: Increased allele value by 2 to include the following
repeat structure: (AAAGG)n(AAGGG)n(AAGGA)2. Formerly, only the
(AAAGG)n(AAGGG)n repeats were counted.
GATA A10
Action taken: Increased allele value by 2 to include the following
repeat structure: (TCCA)2(TATC)n. Formerly, only the (TATC)n repeat was
counted.
GATA H4
Action taken: Locus name has changed to GATA H4.1 to reflect the
correct region of DNA amplification. Allele values will be increased by
10 to include the following repeat structure
(AGAT)4CTAT(AGAT)2(AGGT)3(AGAT)n. Formerly, only the (AGAT)n repeat was
counted.
Adopted allele and locus nomenclature guidelines as set forth by the
International Society of Forensic Genetics: L. Gusmao et. al. Forensic
Science International 157 (2006) 187-197.
Best regards,
The Sorenson Genomics Scientific Leadership Team
This thread: