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Archiver > GENEALOGY-DNA > 2007-08 > 1186022699


From: "Dora Smith" <>
Subject: Re: [DNA] mtDNA H2a phylogeny
Date: Wed, 1 Aug 2007 21:45:08 -0500
References: <bbd.1d4a8f87.33e22945@aol.com>


Yup. History in the making. And I have an idea that those odd mutations
aren't going to hold up. One of them, 1164, claims there is something like
A/C heteroplasmy in a value where the CRS, which is T, transitions to a C,
and I can't find either mutation ever reported before anywhere. So a
mutation that never happened before had to have happened and then partially
mutated further to something else by a more difficult mechanism. I rather
doubt this happened. The results are preliminary; I don't think they've
been checked and now I suppose begins the work of clearing up strange and
ambiguous results.

You know, I am 50 years old, and these were cheek cells. The stuff I found
on mitochondrial disease says that most of it is the result of somatic
mutations, and these muations really pile up after a lifetime. They're a
cause of alzheimers, and of cancer. It should be a miracle if my cheek
cells have only two of them.

The blank spot may be simply a place where the data didn't come out -
though most of the blank areas in the sequence are larger than that.

But I guess we'll have to see.

Yours,
Dora Smith
Austin, TX


----- Original Message -----
From: <>
To: <>
Sent: Wednesday, August 01, 2007 1:21 PM
Subject: Re: [DNA] mtDNA H2a phylogeny


> Dora, I took your preliminary data and figured that
> you may match the CRS except for markers
> 1164, 4763 and 15326. If that is the case, then
> after the CRS, the next closest match at NCBI
> GenBank would be AY339426 with 9 differences
> and after that, DQ523652 with 10 differences and
> this one is in sub-clade H3 according to Ian's Grease
> Monkey analyzer.
>
> So, don't expect any close matches any time soon
> even though there are thousands of CRS-related people
> who could be matches; it is just that no one wants to pay
> for the deeper testing. Consider yourself a pioneer.
>
> Maybe we can encourage others to join the expedition
> to find new matches and to improve the H2 phylogeny.
>
> Kathy J.
>
>
>
>
>
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