GENEALOGY-DNA-L Archives

From:
Subject: Re: [DNA] Topf et al and H sequences [16519C]
Date: Wed, 10 Oct 2007 00:12:35 EDT

In a message dated 10/9/2007 10:47:49 P.M. Central Daylight Time,
writes:

Anne, Can you explain this sentence a little more fully for me--especially
the "16357 (alone)" bit ??
> "I can tell you Sykes found 16357 (alone) in Central England (2
> >observations in his public database)."

Sorry to be such a dunce!

--




Sure! I have extracted all of the H HVS1 data that Bryan Sykes published in
his online Blood of the Isles database at
_http://www.bloodoftheisles.net/OGAP_mDNA.pdf_ (http://www.bloodoftheisles.net/OGAP_mDNA.pdf) and put it into a
database I am building for use in my custom geographic mtDNA reports (along
with other data from published papers etc). He found two samples he
labelled H, which had only the 16357 mutation (he did not analyze 16519, so any
sequence with it would show up in his data as 16357 "alone" -- that is with no
other mutations. While his public database does not seem to be completely
representative of his complete proprietary database (the %s of H in the region do
not tally precisely with the %s he gave in his book, although they aren't
very far off in most cases), it's the best data I have on the British Isles.

Sykes had a couple of other sequences which include 16357 but show
additional mutations in the region of HVR1 that he measured (16050-16400).

I also have one 16357 found by Richards in his 2000 paper, but I cannot tell
where it came from geographically. The H5 Project has a couple with 16304
16357. Both of these are in England, with one specifically coming from
Staffordshire England (which I guess might be in Sykes's "Central England," but I
can't swear to that, since I don't have a good grasp of how his regions are
defined.

There are none in the H Project (although I have not surveyed the H1, H3,
etc. pages looking for them yet.)

So far, these are the only observations of 16357 that I have collected in
studying H. which doesn't mean more don't exist, just that I have not extracted
all the mitotypes that exist in the papers. What I tend to do is collect
the mitotypes my clients have FIRST. The only reason I extracted all the Sykes
data is that so many of my clients come from the British Isles, so I pulled
them as the best available database for that location.

Does that make my statements clearer? If not, ask again!

Anne



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