GENEALOGY-DNA-L ArchivesArchiver > GENEALOGY-DNA > 2007-12 > 1197544642
From: Beth Long <>
Subject: Re: [DNA] Palindromic Testing for ht35 Haplotypes
Date: Thu, 13 Dec 2007 03:17:22 -0800 (PST)
Am I correct that feeling is still that there is a correlation between ht35 and DYS 393=12? If this turns out to be the case, then 12-marker testing would still provide the cheapest "screening device". I assume you are exploring the three-way relationship (ht35=35, DYS393=12, and the palindromic markers)?
I have 11 R1b in my Bukovina project now, three of which have DYS 393=12. Of the remaining people (eight with DYS393=13), one is known to be of ethnic German origin, and one is a known NPE.
Two of them (surname Fabian) appear to be of western European origin (possibly haaving arrived in the area during the middle ages), as there is another Fabian pair with haplogroup I1b2a. No Fabians so far are R1a or I1b (which constitute the majority of the project members).
Thank you for taking the initiative to organize this.
Vincent Vizachero <> wrote: As you deduced, the test proposed is offered by FTDNA.
Panel 5 of their Advanced Orders is a set of palindromic (i.e. multi-
copy) STR markers. In addition to being subject to the regular
forces of repeat count change they are also subject to RecLOH
effects. Since the TaqI 49a,f probes bind to the same region of the
y-chromosome as these palindromic STRs exist, the hope (and it really
is nothing more than hope) is that we can find a credible low-cost
proxy for the ht15/ht35 distinction.
ht15 is widespread throughout western Europe, but virtually non-
existent in central Asia (Al-Zahery found that nearly all the R1b1c
in his Iraqi sample was ht35). European R1b1c Jews are about 50%
ht35 according to Polloni, a fraction which is consistent with the
DYS393=12 levels found in Sean Silver's Jewish R1b project and in
turn consistent with the levels of ht35 found in Cinnioglu's
Anatolian sample. About 30% of Italian R1b1c appears to be ht35,
suggesting Italy as a transition zone between eastern and western
variants of R1b1c.
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