GENEALOGY-DNA-L Archives
Archiver > GENEALOGY-DNA > 2007-12 > 1199127749
From:
Subject: Re: [DNA] Question for Thomas Krahn - STRs in WOY regions
Date: Mon, 31 Dec 2007 14:02:29 EST
In a message dated 12/31/2007 7:20:15 AM Pacific Standard Time,
writes:
> Thomas mentions on p.10 of his .pdf document
> (http://www.dna-fingerprint.com/static/FTDNA-Conference-2007-WalkOnY.pdf) that the cost of full-Y
> sequencing would be "US$ 360,000."
>
> This seems an exaggeration considering that Knome will sequence the entire
> genome (3.2 billion bp) for only $350,000, with private consultation and a
> digital copy included!
>
> My hope is that Knome will listen carefully to the request of those who will
> gladly pay (if reasonable, of course) for full-Y sequencing, perhaps in the
> $5000 - $7000 range, which seems more realistic.
I'm not clear on the technology used by Knome, but I'm not at all sure that
you can scale things down that way. Some of these new methods chop all the DNA
in a cell sample into tiny pieces of a few hundred base pairs, sequence those
short segments, and use computer techniques to align overlapping fragments
into longer contiguous sequences. If that's what Knome is doing, there's no a
priori way to say "just give me the Y." Also, I have a vague memory that one of
the "whole genome" companies is actually just doing gene regions, which would
exclude all that "junk" DNA that we're interested in. I did a quick Google on
that question, but I didn't come up with anything definitive.
Ann Turner
**************************************
See AOL's top rated recipes
(http://food.aol.com/top-rated-recipes?NCID=aoltop00030000000004)
This thread: