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Archiver > GENEALOGY-DNA > 2008-01 > 1199202066


From: "Alfred A. Aburto Jr." <>
Subject: Re: [DNA] SNPs appearing in multiple haplogroups
Date: Tue, 01 Jan 2008 07:41:06 -0800
References: <3b2a446a0712300534i578809fam801efc3ddccb6e32@mail.gmail.com> <BAY103-DAV200903293959FB5F6CBFF3C8570@phx.gbl> <3b2a446a0712302028s5b93b9b9sce9c794595d6f3be@mail.gmail.com> <477873E1.502@familytreedna.com> <3b2a446a0801010605w2fdf0dd7udd4b7fb2dca99da9@mail.gmail.com> <477A50BF.9040601@sbcglobal.net><3b2a446a0801010715k3384481cteb1f9b5977b643b2@mail.gmail.com>
In-Reply-To: <3b2a446a0801010715k3384481cteb1f9b5977b643b2@mail.gmail.com>


Sasson,
The palindromes have two sides (called "arms"). A section of DNA on one
side can replace ("overwrite") the same section of DNA on the other side
(other "arm"). If there is a chance mutation on one side that is not on
the other side then a recLOH event could replace the DNA section having
the mutation with the DNA that didn't have it. The mutation disappears ...

Here is more discussion: http://en.wikipedia.org/wiki/RecLOH
Al


> Sasson Margaliot wrote:

>Al,
>
>What does it mean for a SNP to disappear ?
>Returning to its ancestral value?
>
>Sasson
>
>
>
>On Jan 1, 2008 4:39 PM, Alfred A. Aburto Jr. <> wrote:
>
>
>
>>Sasson,
>>That is my understanding. A SNP in the palindromic region can disappear
>>via a recLOH event. Insertions, inversions, and duplication events can
>>also occur as well. They all occurred apparently in my own palindromic
>>region which is a mess (well, very complicated) :-) ...
>>Al
>>
>>
>>

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