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Archiver > GENEALOGY-DNA > 2008-01 > 1199634531


From:
Subject: Re: [DNA] Are these SNP's tested by deCodeMe ?
Date: Sun, 6 Jan 2008 10:48:51 EST


In a message dated 1/6/2008 7:20:46 AM Pacific Standard Time,
writes:

> Interesting ... however rs2185539 doesn't seem very helpful - which is a
> pity.

You can add rs6650104 to the deCODEme list; I didn't read your message
carefully enough when I picked your numerically sorted list. My little home-brew
utility uses an alphanumeric sort, so I remedied that this time.

> But at least you now know the background to another SNP; and being found
> in a NUMT does at least show this SNP will be medically unimportant.
>
> Perhaps you would care to try looking at 21 more SNPs from a couple
> of NUMTs on Chromosome 5 ?

There's a slightly higher hit rate for this one. Both 23andMe and deCODEme
have rs10515295, while deCODEme also has rs10515294 and rs17764255.

The SNPs in the Illumina BeadChips are picked to provide more-or-less even
coverage across all the chromosomes, with a minor allele frequency of at least
5%. I have the impression that they serve more to map locations of interest to
a specific region on a chromosome, rather than being significant in and of
themselves. There are many millions more SNPs that aren't included in an
off-the-shelf BeadChip. When I read an article about a SNP that's implicated in a
certain trait or condition, it's seldom found on my list.

Ann Turner




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