GENEALOGY-DNA-L Archives

Archiver > GENEALOGY-DNA > 2008-01 > 1200940465


From: (John Chandler)
Subject: Re: [DNA] Markers - How many and which ones?
Date: Mon, 21 Jan 2008 13:34:25 -0500 (EST)
References: <2dff56a0801130620i4a59f886oa1de09a0e8911de1@mail.gmail.com>
In-Reply-To: <2dff56a0801130620i4a59f886oa1de09a0e8911de1@mail.gmail.com>(colin.fergie@gmail.com)


Colin wrote:
> I reexamined your ISOGG paper to see how you
> handled this. So far as I can tell the effect has been modeled as
> though these markers were no different than the non-palindromic
> markers.

Well, a difference is still there -- a mutation to any copy of
a multi-copy marker is counted as a mutation to the marker
collectively. However, the rate determined collectively is
then expressed as a per-copy rate for the purposes of comparing
against the non-palindromic markers and/or computing an
average rate for a set of markers.

John Chandler

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