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Archiver > GENEALOGY-DNA > 2008-02 > 1203866049
From:
Subject: Re: [DNA] 23ANDme versus deCODEme
Date: Sun, 24 Feb 2008 10:14:09 EST
In a message dated 2/24/2008 6:52:49 AM Pacific Standard Time,
writes:
> Can someone bring us up to date on how easy it is for the DNA donor
> to download the complete results from the various companies?
> Coverage of the Y chromosome is of no use to me, but whether I can
> examine the autosomal data for myself in a convenient format would
> make a huge difference in which company I go with.
Yes, you can now download the complete results from both 23andMe (tab
delimited) and deCODEme (comma delimited). Both companies have columns for the rs
number, chromosome, chromosome position, and genotype.
There is a slight difference in reporting conventions: 23andMe always reports
the alleles on the "plus" strand, while deCODEme reports the alleles in
whatever orientation is used by dbSNP (which can be plus or minus). Also, deCODEme
has a column with the alleles listed at dbSNP.
It's easy enough to convert minus alleles to plus alleles (I wrote a
home-brew BASIC program to do that), but the 23andMe download doesn't contain the
information to go in the opposite direction. You can look up each SNP individually
in their genome browser if you need to know. I've noticed that technical
articles aren't very consistent in the way they report alleles. It may depend on
what genotyping platform they used, and whether the plus/minus orientation
seemed more robust. DNAPrint explained that their results reflected the way they
came out on their genotyping methodology.
SeqWright (private communication) also said that feature would be available,
but I haven't heard from anyone who has ordered a test from SeqWright.
SeqWright uses a chip from Affymetrix.
Ann Turner
**************
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