GENEALOGY-DNA-L Archives

Archiver > GENEALOGY-DNA > 2008-02 > 1203873873


From: "Eldon Wade" <>
Subject: Re: [DNA] 23ANDme versus deCODEme
Date: Sun, 24 Feb 2008 12:24:33 -0500
References: <538587.14067.qm@web50701.mail.re2.yahoo.com>
In-Reply-To: <538587.14067.qm@web50701.mail.re2.yahoo.com>


David,

I tested with deCODEme. Of their 1,071,000 targeted SNPs I received results
on 1,013,349. Of these, 162 were mtDNA, 858 were Y-SNPs, 36,589 were
X-SNPs, and 975,740 were autosomal SNPs.

>From the 162 mtDNA they test they reported all the mutations I discovered
from my FGS except 73G and 7691C (deCODEme does not test 73G or 7691C).

When comparing my 858 Y-SNPs to the HUGO reference there were 28 variations.
10 of these variations I shared with both Dr. Venter and Dr. Watson who are
also R1b1c9. I have 4 variations I share with Dr. Venter only. Thus I have
14 variations that I do not share with either Dr. Venter or Dr. Watson.

I am still working on my X-SNP results but what it has already divulged is
my maternal line has far more non-European ancestry than I once thought it
had. Is that Asian or Native American ancestry I am seeing or both? A
rhetorical question. Anyway, I am anxious for more people to take this test
and share their X-SNP results.

I downloaded from the University of Chicago the ancestral values for 893,740
autosomal SNPs. I compared the U of C SNPs with ancestral values to my
975,740 autosomal results. This provided ancestral values for 373,397 of my
975,740 autosomal SNP results from deCODEme. I am still looking for
ancestral values for 602,343 of my autosomal SNP results.
Of the 373,397 SNPs I have test results for (and I know the ancestral values
for these SNPs) I have 161,478 SNPs that are ancestral at both bases and I
have 92,066 SNPs that are not ancestral at either base.

I believe that all of this info is useful now and will be even more useful
as more people take the deCODEme test and share the results with us.

By the way, I have been in contact with both the deCODEme tech support and
deCODEme consultation people and they are very quick to respond and are
helpful.

Eldon


-----Original Message-----
From:
[mailto:] On Behalf Of David Faux
Sent: Saturday, February 23, 2008 7:32 PM
To: DNA Rootsweb
Subject: [DNA] 23ANDme versus deCODEme

Ann and List:

I am still wrestling with which company to employ in a genome scan of 1
million or so SNPs to shed light on ancestry, physical traits, medical
conditions (risk assessment) and so on.

Never being one to reinvent the wheel, I will ask on the eve of my
decision for some input as to whether at this point one company's offering
stands out above that of the other in any of the above categories. Clearly
a grand is a fair bit of coin, so the choice must be made wisely
(particularly so since retirement is looming and an opportunity to fund this
sort of endeavor may not come along again for a while).

Whether on-List of off-List I would very much appreciate an assessment
(even very brief) of the merits of turning to one company or the other. Now
that 23ANDme has a Y-chromosome component to their testing, they are very
much in the game as far as I am concerned. However they seem to measure
only about 2/3 the number of raw SNPs as deCODEme - which is certainly a
consideration / concern.

Thanks for any help the pioneers can offer to me as I weight the blessings
of each option.

David K. Faux.

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