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From: Gareth Henson <>
Subject: Re: [DNA] Comparison of deCODEme results for the Y-chromosome ofR1b1c7and R1b1c9 individuals
Date: Sat, 01 Mar 2008 01:35:16 +0000


David

I have been given access to results from an individual in haplogroup G5 and I have been given permission to report to the list that for rs34276300 he has the C allele - in common with all the R1b1c9 results (including Venter and Watson). In the results I am aware of, only your R1b1c7 individual and the HUGO reference sequence have the A allele. This suggests that the C allele is ancestral and the A allele is derived, which means that this SNP could be associated with M222 (either equivalent or just upstream or downstream of it).

I had not noticed this before, but M222 is in the AZFa region which was sequenced separately, so the fact that the reference sequence is negative for M222 doesn't tell us anything about the M222 status of the main donor.

There may be other explanations for this SNPs odd results so any additional data, from inside and outside R1b1c, will be very useful.

Gareth

----- Original Message -----
From: "David Wilson" <>
To: <>
Sent: Sunday, February 24, 2008 5:29 PM
Subject: [DNA] Comparison of deCODEme results for the Y-chromosome of
R1b1c7and R1b1c9 individuals


> Through the courtesy of two individuals who provided me with their
deCODEme
> results for the Y chromosome, I have been able to compare Y-DNA SNPs for
> R1bc7 and R1b1c9 exemplars.
>
> Of the 858 separate loci, 855 are identical. The three at which a
difference
> is observed are:
>
> rs20321 (= M222, indicator for R1b1c7 when derived)
> rs16981293 (= S21/U106, indicator for R1b1c9 when derived)
> rs34276300 (to my knowledge, no shorthand label exists)
>
> For the third SNP, the R1b1c7 individual has the ancestral state, and the
> R1b1c9 individual shows the derived state. Comparison of the Crick and
> Venter data show that they too have the derived state.
>
> It would be interesting to know whether the third SNP is restricted to
those
> who are derived for S21/U106, or whether it is a unifying SNP that will
> combine R1b1c9 with other subhaplogroups of R1b1c.
>
>
> David Wilson

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