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From: "Alister John Marsh" <>
Subject: Re: [DNA] S21/S28 Split+m223 stuff
Date: Thu, 22 May 2008 09:38:07 +1200
References: <200805211517.m4LFH0lt016615@mail.rootsweb.com><010d01c8bb5c$c8c5a300$6400a8c0@Ken1>
In-Reply-To: <010d01c8bb5c$c8c5a300$6400a8c0@Ken1>


Ken,

I wonder what would happen if you applied your formula separately to the 33
fastest mutating markers, and 34 slowest mutating markers for the same sets
of 67 marker data. (or 20 fastest markers compared to 47 slowest markers)

Would the fast markers give the same MRCA results as the slow markers?

In the faster set of markers, there may be more hidden back mutations, and
it might distort apparent ages of common ancestors.

If you only had a single fast marker, and gave it time to mutate 100 times,
you would statistically expect 50 up and 50 down mutations, so end up close
to where you started. If you have a set of very slow markers, which would
likely only mutate once in a given time frame, say since S116+, the formula
would not be distorting the TMRCA.

John

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