GENEALOGY-DNA-L ArchivesArchiver > GENEALOGY-DNA > 2008-06 > 1213086201
From: "Elizabeth O'Donoghue" <>
Subject: Re: [DNA] mushing
Date: Tue, 10 Jun 2008 09:23:21 +0100
Ken, your explanation of weighting helped me a great deal - and without even
one equation in it! Much appreciated.
Does it mean that since all the markers used have different speeds of
mutation, the weighting in used in order to arrive at an average mutation
rate when calculating against the total genetic distance between two (or
multiple) haplotypes? Does that take into account whether a genetic
distance of one, for instance, between haplotypes is a slow mutating marker
rather than a fast marker?
I know that FTDNA's TiP calculator will provide different generational
distances between different pairs of haplotypes which may have the same
genetic distance but mismatches at different markers, so it must take into
account the relative mutation rate of each marker individually. I know I've
read on the list, perhaps even from yourself, that the different mutation
rates between various markers in the selection used make little difference
to overall TMRCA, so that average mutation rates are used in the
calculations; but I would think that the longer the time distance between
haplotypes, the more likely it would be to make a difference in the result.
Thanks again. Elizabeth
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