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Archiver > GENEALOGY-DNA > 2008-07 > 1215795283


From: "Sandy Paterson " <>
Subject: Re: [DNA] calibrating for common ancestor - QUESTION?
Date: Fri, 11 Jul 2008 17:54:43 +0100
References: <mailman.89372.1215791041.8264.genealogy-dna@rootsweb.com><4.3.1.2.20080711120512.043d9008@mail.spacey.net>
In-Reply-To: <4.3.1.2.20080711120512.043d9008@mail.spacey.net>


Hi John/Ken

Thanks - I have a clear understanding of the difference and its importance
it's just that my terminology is a little archaic.

The collection of what I've called 'known ex-ante modes' makes up the
founder haplotype, a much better expression in this context.

The collection of 'observed ex-post modes' makes up the haplogroup modal.

Sandy



-----Original Message-----
From:
[mailto:] On Behalf Of John E. Mellick
Sent: 11 July 2008 17:23
To:
Subject: Re: [DNA] calibrating for common ancestor - QUESTION?

Sandy,
Ken mentioned there is a difference between Modal haplotype (most common
allele at each loci, determined independently from the others) and the
founding haplotype. To better understand this difference, you might enjoy
reading Kerchner's method of determining the deduced ancestral haplotype,
using triangulation. See:
http://www.kerchner.com/triangulation.htm
JohnM

>Ken said:
>The founding haplotype needs to be known and used for the mentioned
>variance. It could differ from the modal haplotype of the sample
>population. I know it is reasonable to estimate that founding haplotype
>from the modal haplotype in most cases, but it is important to remember the
>distinction and that they sometimes will differ. One can play around and
>quantify how much error in G estimation one will make if an error on one or
>more markers is made in picking the founding haplotype.
>Ken


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