GENEALOGY-DNA-L Archives

From:
Subject: Re: [DNA] Similarity at 23andME
Date: Wed, 1 Oct 2008 13:05:24 EDT

The offsets you see for base numbers in 23andMe's browser are not related to
whether you *personally* have inserts at 309. The chip uses the Yoruba
Reference Sequence, which differs from the CRS in several respects. The net result is
that the offsets will vary for different regions of the mtDNA molecule.

Larry gave the URL for a spreadsheet I developed for version 1 of the chip:

http://members.aol.com/dnacousins/CRS_lookup_with_23andMe_SNPs.xls

You can use it to see the offsets for the Yoruba Reference Sequence and the
CRS, but it's not ready for prime time for people who have raw data from
version 2 of the chip. There are several issues I need to clarify with 23andMe.

Ann Turner


In a message dated 10/1/2008 8:56:05 AM Pacific Daylight Time,
writes:

> Thank you for showing me where to find everything!
>
> Apparently 23andMe is testing more mtDNA SNPs these
> days. But my 16393 was incorrectly reported. Maybe it is
> because they only tested for 16393A and T but not G.
> Perhaps they picked up some heteroplasmy? I am
> supposed to be G, not A.
>
> I was wondering if you were also given an extra "C"
> at the 309.1 position. SMGF and FTDNA both report
> my results as just 309.1C but not 309.2C. At
> 23andMe they are picking up the extra 309.2C which
> then shifts the higher numbers away from the CRS
> by 2 instead of a shift of 1. This is just another
> example of why you should ignore this extra C
> when comparing results with other people.
>




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