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Archiver > GENEALOGY-DNA > 2009-04 > 1238780045


From: Vincent Vizachero <>
Subject: Re: [DNA] Comparison of Chinese, Yoruba,Watson and Venter genome y-snps
Date: Fri, 3 Apr 2009 13:34:05 -0400
References: <49D63D29.6090009@ucl.ac.uk>
In-Reply-To: <49D63D29.6090009@ucl.ac.uk>


James,

Thanks for pulling this all together. I want to dig into it, but re:
the comment below I think the first presumption should always be that
the quality of the sequences is suspect. I know that seems like a cop-
out, but full genome sequencing is inherently error-prone. Many early
mtDNA dating efforts were wrong because the sequence data was wrong,
even while the method itself is fundamentally sound.

Your doing exactly the right kind of analysis, but we must all be
aware at just how crappy the data could be.

VV


On Apr 3, 2009, at 12:45 PM, James Heald wrote:

> And if they could, does that mean the dating method used in Karafet et
> al (2008) now looks very questionable?

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