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Archiver > GENEALOGY-DNA > 2010-02 > 1265504060


From: John E Mellick <>
Subject: Re: [DNA] Variance Assessment
Date: Sat, 06 Feb 2010 19:54:20 -0500
In-Reply-To: <e8a29dad1ef362b5c284b30060aca260f91b52c3@localhost>


Dear Anatole,

I think 67 X 0.00216 is 0.145, not 0.0145

John

At 04:46 PM 2/6/2010 -0700, you wrote:
> 8. Re: Variance Assessment of R:U106 DYS425Null Cluster
> (Anatole Klyosov)
>---------------------
>
>Dear Ken, Andrew and Sandy,
>
>-- First, that mutations in haplotypes happen randomly, and actually serve
>as a molecular clock for hundreds of thousand years, and probably for
>million years.
>-- Second, that mutations have their own mutation rate constant in each
>locus, and by combining those loci (as haplotypes) we can sum those mutation
>rates up and operate with average mutation rate constants per marker and per
>haplotype. I have found that those mutation rate constants give the best
>results at 0.022 mutations per the 12-marker haplotype (0.00183 mutations
>per marker in that panel), 0.046 mutations per the 25-marker haplotype
>(0.00183 mutations per marker), 0.090 mutations per the 37-marker haplotype
>(0.00243 mutations per marker), and 0.0145 mutations per the 67-marker
>haplotype (0.00216 mutation per marker).


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