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From: "RICHARD KENYON" <>
Subject: Re: [DNA] News item: first ancient human genome sequenced
Date: Wed, 10 Feb 2010 17:15:18 -0800
References: <e4dd.3fa9ee07.38a46414@aol.com>
In-Reply-To: <e4dd.3fa9ee07.38a46414@aol.com>


The 11 Feb 2010 issue of Nature contains a very interesting (and important) article by Rasmussen et al, "Ancient human genome sequence of an extinct Palaeo-Eskimo", pp. 757-762. The DNA from a tuft of hair found in permafrost in Greenland, dated about 4000 bp, is extensively analyzed. They have apparently been able to do a more complete sequencing job of the genome than has been possible for the Neanderthals. They mention, for example, finding 4024 SNPs on the Y, of which they call 243 to be of "high confindence" and a total of 353,151 for the what they call the Saqqaq genome. The haplogroup is stated as Q1a*. They were also able to draw various conclusions about the phenotype of the Saqqaq man. Interestingly, they don't seem to have had a problem extracting DNA from hair samples. The supplementary information (only obtainable on-line) is quite extensive, being 87 pages long.

Richard R. Kenyon ("Dick")
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Sent: Wednesday, February 10, 2010 11:33 AM
Subject: [DNA] News item: first ancient human genome sequenced


Yup, the whole thing (or pretty much):

http://www.the-scientist.com/blog/display/57140/<http://www.the-scientist.com/blog/display/57140/>;

It's the cover article in the February 11 issue of Nature,

http://www.nature.com/nature/<http://www.nature.com/nature/>;

Only the supplementary material appears to be freely available online

http://www.nature.com/nature/journal/v463/n7282/extref/nature08835-s1.pdf<http://www.nature.com/nature/journal/v463/n7282/extref/nature08835-s1.pdf>;

Ann Turner

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