GENEALOGY-DNA-L Archives

Archiver > GENEALOGY-DNA > 2010-02 > 1265989895


From: Vincent Vizachero <>
Subject: Re: [DNA] Variance Assessment wrt back and parallel mutations
Date: Fri, 12 Feb 2010 10:51:35 -0500
References: <mailman.4304.1265934440.2099.genealogy-dna@rootsweb.com><62BE85974A2B4FD8ABA4CF2E9BF468D3@anatoldesktop><59b150b1002120606j3ec30612v69ea93f9941a371e@mail.gmail.com>
In-Reply-To: <59b150b1002120606j3ec30612v69ea93f9941a371e@mail.gmail.com>


In addition to testing more branches, the other solution is to test
more STRs (especially ones with a higher probability of mutation).

In designing a testing panel with maximum phylogenetic resolution, the
goal is generally to maximize the sum of mutation rates and minimize
the variance of the mutation rates. Failing that, in practice for
genealogical studies simply maximizing the number of fast mutators
would be a good approximation. With the caveat that multi-copy
markers are harder to interpret than single copy markers.

VV


On Feb 12, 2010, at 9:06 AM, Robert Stafford wrote:

> However, testing other branches may resolve
> the question in the former case and will usually do so in the latter.


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