Archiver > GENEALOGY-DNA > 2010-02 > 1266443227

From: Charles Hollenbeck <>
Subject: Re: [DNA] Complete Khoisan and Bantu genomes from southern Africareported in Nature this week
Date: Wed, 17 Feb 2010 13:47:07 -0800
References: <COL123-DS17BEB6ACFA1E64140E49C5C8480@phx.gbl>
In-Reply-To: <COL123-DS17BEB6ACFA1E64140E49C5C8480@phx.gbl>

Thanks, Dick. Wouldn't have seen this if you hadn't pointed it out.

I was hoping something like this would occur, but there wasn't much
chance of a San or Khoikhoi having the money to do it.

On Wed, Feb 17, 2010 at 12:20 PM, RICHARD KENYON <>wrote:

> The genomes of two South Africans representing very early lineages have
> been sequenced, as reported in the following article from the latest issue
> of Nature, dated 17 Feb 2010. The title of the article is:
> Complete Khoisan and Bantu genomes from southern Africa
> The authors' summary is:
> The genetic structure of the indigenous hunter-gatherer peoples of southern
> Africa, the oldest known lineage of modern human, is
> important for understanding human diversity. Studies based on mitochondrial
> and small sets of nuclear markers have shown that
> these hunter-gatherers, known as Khoisan, San, or Bushmen, are genetically
> divergent from other humans. However, until now,
> fully sequenced human genomes have been limited to recently diverged
> populations. Here we present the complete genome
> sequences of an indigenous hunter-gatherer from the Kalahari Desert and a
> Bantu from southern Africa, as well as protein-coding
> regions from an additional three hunter-gatherers from disparate regions of
> the Kalahari. Wecharacterize the extent of whole-genome
> and exome diversity among the fivemen, reporting 1.3 million novel DNA
> differences genome-wide, including 13,146 novel amino acid
> variants. In terms of nucleotide substitutions, the Bushmen seem to be, on
> average, more different from each other than, for example, a
> European and an Asian. Observed genomic differences between the
> hunter-gatherers and others may help to pinpoint genetic adaptations
> to an agricultural lifestyle. Adding the described variants to current
> databases will facilitate inclusion of southern Africans in
> medical research efforts, particularly when family and medical histories
> can be correlated with genome-wide data.
> Richard R. Kenyon ("Dick")
> -------------------------------
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