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Archiver > GENEALOGY-DNA > 2010-02 > 1266446867


From: Robert Stafford <>
Subject: Re: [DNA] TMRCA assessments
Date: Wed, 17 Feb 2010 16:47:47 -0600
References: <1E3D9E5FCDAF45A287866936EFD0FF5F@anatoldesktop>
In-Reply-To: <1E3D9E5FCDAF45A287866936EFD0FF5F@anatoldesktop>


Did you calibrate the rate constants as rate per haplotype per year and
divide by 25 to get the per-generation value or did you calculate the latter
directly?

Bob Stafford

On Wed, Feb 17, 2010 at 5:56 AM, Anatole Klyosov <>wrote:

> More on the subject.
>
> A calibration requires two things: (1) knowing (or assuming) a time span to
> the event, being considered for the calibration, and (2) a total number of
> mutations that occurred in the haplotype dataset compared to the base
> haplotype. Oh, yes, and a proof that both linear and the logarithmic
> methods
> give the same value (for that you do not need a mutation rate constant),
> that is M/G = ln(G/n). Here M = a number of mutations in the dataset, G is
> a
> number of haplotypes in the dataset, and n is a number of base haplotypes
> in
> the dataset.
>
>


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