Archiver > GENEALOGY-DNA > 2010-02 > 1266843101

From: steven perkins <>
Subject: [DNA] Article: A genome-wide survey does not show the geneticdistinctiveness of Basques
Date: Mon, 22 Feb 2010 07:51:41 -0500

A genome-wide survey does not show the genetic distinctiveness of Basques
JournalHuman Genetics
PublisherSpringer Berlin / Heidelberg
ISSN0340-6717 (Print) 1432-1203 (Online)
CategoryShort Report
Subject CollectionBiomedical and Life Sciences
SpringerLink DateMonday, February 15, 2010

Online First™
PDF (246.4 KB)HTMLFree PreviewFree PreviewSupplemental
MaterialSupplemental Material

Short Report

A genome-wide survey does not show the genetic distinctiveness of Basques

Hafid Laayouni1, 2 Contact Information, Francesc Calafell1, 2 and
Jaume Bertranpetit1, 2
(1) IBE, Institute of Evolutionary Biology (UPF-CSIC),
CEXS-UPF-PRBB, Doctor Aiguader 88, 08003 Barcelona, Catalonia, Spain
(2) Centro de Investigación Biomédica En Red, Epidemiología y Salud
Pública (CIBERESP), Barcelona, Spain

Received: 27 October 2009 Accepted: 1 February 2010 Published
online: 16 February 2010
Abstract Basques are a cultural isolate, and, according to mainly
allele frequencies of classical polymorphisms, also a genetic isolate.
We investigated the differentiation of Spanish Basques from the rest
of Iberian populations by means of a dense, genome-wide SNP array. We
found that F ST distances between Spanish Basques and other
populations were similar to those between pairs of non-Basque
populations. The same result is found in a PCA of individuals, showing
a general distinction between Iberians and other South Europeans
independently of being Basques. Pathogen-mediated natural selection
may be responsible for the high differentiation previously reported
for Basques at very specific genes such as ABO, RH, and HLA. Thus,
Basques cannot be considered a genetic outlier under a general genome
scope and interpretations on their origin may have to be revised.
Electronic supplementary material The online version of this article
(doi:10.1007/s00439-010-0798-3) contains supplementary material, which
is available to authorized users.

Contact Information Hafid Laayouni

Steven C. Perkins
Online Journal of Genetics and Genealogy
Steven C. Perkins' Genealogy Page
Steven C. Perkins' Genealogy Blog

This thread: