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From: steven perkins <>
Subject: [DNA] Article: A genome-wide survey does not show the geneticdistinctiveness of Basques
Date: Mon, 22 Feb 2010 07:51:41 -0500


A genome-wide survey does not show the genetic distinctiveness of Basques
JournalHuman Genetics
PublisherSpringer Berlin / Heidelberg
ISSN0340-6717 (Print) 1432-1203 (Online)
CategoryShort Report
DOI10.1007/s00439-010-0798-3
Subject CollectionBiomedical and Life Sciences
SpringerLink DateMonday, February 15, 2010

http://www.springerlink.com/content/k24743n504551128/

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Short Report

A genome-wide survey does not show the genetic distinctiveness of Basques

Hafid Laayouni1, 2 Contact Information, Francesc Calafell1, 2 and
Jaume Bertranpetit1, 2
(1) IBE, Institute of Evolutionary Biology (UPF-CSIC),
CEXS-UPF-PRBB, Doctor Aiguader 88, 08003 Barcelona, Catalonia, Spain
(2) Centro de Investigación Biomédica En Red, Epidemiología y Salud
Pública (CIBERESP), Barcelona, Spain

Received: 27 October 2009 Accepted: 1 February 2010 Published
online: 16 February 2010
Abstract Basques are a cultural isolate, and, according to mainly
allele frequencies of classical polymorphisms, also a genetic isolate.
We investigated the differentiation of Spanish Basques from the rest
of Iberian populations by means of a dense, genome-wide SNP array. We
found that F ST distances between Spanish Basques and other
populations were similar to those between pairs of non-Basque
populations. The same result is found in a PCA of individuals, showing
a general distinction between Iberians and other South Europeans
independently of being Basques. Pathogen-mediated natural selection
may be responsible for the high differentiation previously reported
for Basques at very specific genes such as ABO, RH, and HLA. Thus,
Basques cannot be considered a genetic outlier under a general genome
scope and interpretations on their origin may have to be revised.
Electronic supplementary material The online version of this article
(doi:10.1007/s00439-010-0798-3) contains supplementary material, which
is available to authorized users.

Contact Information Hafid Laayouni
Email:

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Steven C. Perkins
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