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From: Tom Gull <>
Subject: Re: [DNA] Article: A genome-wide survey does not show thegenetic distinctiveness of Basques
Date: Mon, 22 Feb 2010 09:45:54 -0500
References: <da404fe11002220451o441a4798g6496f34ae8c7c88@mail.gmail.com>
In-Reply-To: <da404fe11002220451o441a4798g6496f34ae8c7c88@mail.gmail.com>


That's not good news for the "R1b was the dominant haplogroup in the Ice Age Franco-Cantabrian refuge" hypothesis which was partly propped up by the concept that the Basque Y-DNA was aboriginal to the area and thus R1b had been there way back... / Tom

> Date: Mon, 22 Feb 2010 07:51:41 -0500
> From:
> To:
> Subject: [DNA] Article: A genome-wide survey does not show the genetic distinctiveness of Basques
>
> A genome-wide survey does not show the genetic distinctiveness of Basques
> Journal Human Genetics
> Publisher Springer Berlin / Heidelberg
> ISSN 0340-6717 (Print) 1432-1203 (Online)
> Category Short Report
> DOI 10.1007/s00439-010-0798-3
> Subject Collection Biomedical and Life Sciences
> SpringerLink Date Monday, February 15, 2010
>
> http://www.springerlink.com/content/k24743n504551128/
>
> Online First™
> PDF (246.4 KB)HTMLFree PreviewFree PreviewSupplemental
> MaterialSupplemental Material
>
> Short Report
>
> A genome-wide survey does not show the genetic distinctiveness of Basques
>
> Hafid Laayouni1, 2 Contact Information, Francesc Calafell1, 2 and
> Jaume Bertranpetit1, 2
> (1) IBE, Institute of Evolutionary Biology (UPF-CSIC),
> CEXS-UPF-PRBB, Doctor Aiguader 88, 08003 Barcelona, Catalonia, Spain
> (2) Centro de Investigación Biomédica En Red, Epidemiología y Salud
> Pública (CIBERESP), Barcelona, Spain
>
> Received: 27 October 2009 Accepted: 1 February 2010 Published
> online: 16 February 2010
> Abstract Basques are a cultural isolate, and, according to mainly
> allele frequencies of classical polymorphisms, also a genetic isolate.
> We investigated the differentiation of Spanish Basques from the rest
> of Iberian populations by means of a dense, genome-wide SNP array. We
> found that F ST distances between Spanish Basques and other
> populations were similar to those between pairs of non-Basque
> populations. The same result is found in a PCA of individuals, showing
> a general distinction between Iberians and other South Europeans
> independently of being Basques. Pathogen-mediated natural selection
> may be responsible for the high differentiation previously reported
> for Basques at very specific genes such as ABO, RH, and HLA. Thus,
> Basques cannot be considered a genetic outlier under a general genome
> scope and interpretations on their origin may have to be revised.
> Electronic supplementary material The online version of this article
> (doi:10.1007/s00439-010-0798-3) contains supplementary material, which
> is available to authorized users.
>
> Contact Information Hafid Laayouni
> Email:
>
> --
> Steven C. Perkins
> http://stevencperkins.com/
> Online Journal of Genetics and Genealogy
> http://jgg-online.blogspot.com/
> Steven C. Perkins' Genealogy Page
> http://stevencperkins.com/genealogy.html
> Steven C. Perkins' Genealogy Blog
> http://scpgen.blogspot.com/
>
>
> -------------------------------
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