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From: "Lawrence Mayka" <>
Subject: [DNA] mtDNA X1 in Eastern Europe
Date: Tue, 23 Feb 2010 19:49:45 -0600


My project has 18 members of mtDNA X, 10 of them with HVR2 results. Until
recently, I did not examine these results closely against the subclade
definitions; I simply accepted the conventional wisdom that X1 only reached
as far as the Middle East, and hence all mtDNA X in my project belonged to
X2. Until today, only one of these project members had undergone an FGS,
and the result was X2b. That member appears to have Ashkenazi matrilineage.

Today, a project member's FGS result was X1, with the following control
region:

16183C,16185T,16189C,16223T,16266T,16274A,16278T,16390A
73G,146C,152C,195C,263G,309.1C,315.1C

Ashkenazi matrilineal ancestry is unlikely.

I compared this with the tree at phylotree.org, and soon realized that the X
tree at that web site bears very little correspondence to Eastern European
reality. The tree shows X1 defined by a 146 mutation. My project has
plenty of those, including both the known X1 above and the known X2b:

(known X2b, Ashkenazi, plus 2 more who match HVR1+HVR2)
16183C,16189C,16223T,16278T,16519C
73G,146C,153G,195C,198T,225A,226C,263G,309.1C,315.1C

(Ashkenazi unlikely)
16183C,16189C,16223T,16266T,16274A,16278T,16390A,16519C
73G,146C,152C,195C,263G,315.1C

So let's say that the known X2b and its matches constitute a rare subclade
with an independent 146 mutation. Is the other one a probable X1 on account
of that same 146C mutation? All have 195C, usually associated with X2, but
look again above--the known X1 also has 195C. So neither 146C nor 195C
really distinguishes between X1 and X2 at all.

Moreover: A 153 mutation is typical of X except for certain subclades
within X2. But neither the known X1 nor the probable X1 have that.

So perhaps we are to conclude that:

1) Poland has native X1, otherwise unknown outside Africa and the Middle
East.

2) Control-region mutations on the official phylotree for X should be
ignored.



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