GENEALOGY-DNA-L Archives

Archiver > GENEALOGY-DNA > 2010-02 > 1267167622


From: Anders Pålsen <>
Subject: [DNA] Re Clerical mutations and lab errors
Date: Thu, 25 Feb 2010 23:00:22 -0800 (PST)
In-Reply-To: <REME20100225202615@alum.mit.edu>


So could these lab errors contribute to a overestimated mutation rate versus Zhiv rates?

Anders

--- Den fre 2010-02-26 skrev John Chandler <>:

> I have a statistic that may interest
> some of you.  In 2008, I visited
> a large number of Y DNA project web pages and collected a
> substantial
> number of 67-marker haplotypes -- about 10,000 in all -- in
> my effort
> to get an improved set of relative mutation rates. 
> Alas, I found that
> number to be still too few.  Recently, I began
> revisiting most of
> those same projects to expand my collection, and, because
> it is
> easiest to collect everything during a visit, I now have
> two snapshots
> separated by almost two years.  About 9,000 haplotypes
> appear in both
> snapshots, and nearly all of them are the same both times
> -- but not
> quite all.  25 have changed in the meantime, and 10 of
> those 25 are in
> projects with www.ftdna.com/public pages that provide a
> direct window
> into the FTDNA results database.  Indeed, about 8,000
> of the
> haplotypes in play were found in such projects.
>
> Note: the duplicate haplotypes found for testees who belong
> to
> multiple projects have been weeded out.  These are
> 8,000 distinct
> haplotypes.
>
> Thus, I have a reading on the discovery rate for lab
> errors, including
> clerical errors at the lab: 1 per 800 haplotypes.  You
> can divide by
> 67 if you want the per-marker error rate, but I don't have
> enough
> events to say how the error probability is distributed
> among the
> various markers.  It's surely not distributed evenly.
>
> Note the much higher error rate (including clerical errors
> by project
> webmasters) for the results found only on privately
> maintained web
> sites: 1 per 67 haplotypes.
>
> RECOMMENDATION: even though your project may have members
> who tested
> at other labs besides FTDNA, go ahead and set up a "public"
> web site
> at FTDNA as well.
>
>            
>         John Chandler


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