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From: Ann Turner <>
Subject: [DNA] PubMed abstract: Legacy of Mutiny on the Bounty
Date: Sun, 28 Feb 2010 09:15:13 -0800


Eur J Hum Genet. 2010 Jan;18(1):67-72.

Legacy of mutiny on the Bounty: founder effect and admixture on Norfolk Island.

Macgregor S, Bellis C, Lea RA, Cox H, Dyer T, Blangero J, Visscher PM,
Griffiths LR.

Queensland Institute of Medical Research, Brisbane, QLD, Australia.

The population of Norfolk Island, located off the eastern coast of
Australia, possesses an unusual and fascinating history. Most
present-day islanders are related to a small number of the 'Bounty'
mutineer founders. These founders consisted of Caucasian males and
Polynesian females and led to an admixed present-day population. By
examining a single large pedigree of 5742 individuals, spanning >200
years, we analyzed the influence of admixture and founder effect on
various cardiovascular disease (CVD)-related traits. On account of the
relative isolation of the population, on average one-third of the
genomes of present-day islanders (single large pedigree individuals)
is derived from 17 initial founders. The proportion of Polynesian
ancestry in the present-day individuals was found to significantly
influence total triglycerides, body mass index, systolic blood
pressure and diastolic blood pressure. For various cholesterol traits,
the influence of ancestry was less marked but overall the direction of
effect for all CVD-related traits was consistent with Polynesian
ancestry conferring greater CVD risk. Marker-derived homozygosity was
computed and agreed with measures of inbreeding derived from pedigree
information. Founder effect (inbreeding and marker-derived
homozygosity) significantly influenced height. In conclusion, both
founder effect and extreme admixture have substantially influenced the
genetic architecture of a variety of CVD-related traits in this
population.

PMID: 19584896 [PubMed - indexed for MEDLINE]


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