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Archiver > GENEALOGY-DNA > 2010-02 > 1267383302


From: Wilcox Lisa <>
Subject: Re: [DNA] PubMed abstract: Legacy of Mutiny on the Bounty
Date: Sun, 28 Feb 2010 10:55:02 -0800
References: <9b93505e1002280915oe33dcd8r209cfd5b6bfeba0f@mail.gmail.com>
In-Reply-To: <9b93505e1002280915oe33dcd8r209cfd5b6bfeba0f@mail.gmail.com>


Hah. Is there a term for the genetic results of centuries of routine,
culturally-accepted incest and child-rape?


Lisa, who has not had enough coffee yet, either


On Feb 28, 2010, at 9:15 AM, Ann Turner wrote:

> Eur J Hum Genet. 2010 Jan;18(1):67-72.
>
> Legacy of mutiny on the Bounty: founder effect and admixture on
> Norfolk Island.
>
> Macgregor S, Bellis C, Lea RA, Cox H, Dyer T, Blangero J, Visscher PM,
> Griffiths LR.
>
> Queensland Institute of Medical Research, Brisbane, QLD, Australia.
>
> The population of Norfolk Island, located off the eastern coast of
> Australia, possesses an unusual and fascinating history. Most
> present-day islanders are related to a small number of the 'Bounty'
> mutineer founders. These founders consisted of Caucasian males and
> Polynesian females and led to an admixed present-day population. By
> examining a single large pedigree of 5742 individuals, spanning >200
> years, we analyzed the influence of admixture and founder effect on
> various cardiovascular disease (CVD)-related traits. On account of the
> relative isolation of the population, on average one-third of the
> genomes of present-day islanders (single large pedigree individuals)
> is derived from 17 initial founders. The proportion of Polynesian
> ancestry in the present-day individuals was found to significantly
> influence total triglycerides, body mass index, systolic blood
> pressure and diastolic blood pressure. For various cholesterol traits,
> the influence of ancestry was less marked but overall the direction of
> effect for all CVD-related traits was consistent with Polynesian
> ancestry conferring greater CVD risk. Marker-derived homozygosity was
> computed and agreed with measures of inbreeding derived from pedigree
> information. Founder effect (inbreeding and marker-derived
> homozygosity) significantly influenced height. In conclusion, both
> founder effect and extreme admixture have substantially influenced the
> genetic architecture of a variety of CVD-related traits in this
> population.
>
> PMID: 19584896 [PubMed - indexed for MEDLINE]
>
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