GENEALOGY-DNA-L Archives

Archiver > GENEALOGY-DNA > 2010-03 > 1268717162


From: vernade didier <>
Subject: [DNA] Re : Usefulness of SNP tests
Date: Tue, 16 Mar 2010 05:26:02 +0000 (GMT)
In-Reply-To: <002b01cac4c5$0dec6cc0$0201a8c0@NicksCompaq>


Until now the best results from 23andME are the Y SNPs and those SNPs used by Relative Finder . You also get SNP testing on mtDNA .

Didier

> I am trying to convince myself of the
> value of massive SNP tests like that offered by 23andMe.
> Their Complete test covers both genealogy and health areas.
> Am I wrong in thinking that detecting latent defective
> genes (ie as a carrier) is a very hit & miss affair? I
> opened a free account and browsed the chromosomes of the
> "Mendel" family and found that the number of SNPs offered
> for a particular gene is a long way short of the constituent
> nucleotide pairs (possible mutations). A lot were in
> introns, not that that necessarily rules out an effect on
> protein functionality. I know that some mutations are
> concentrated on one locus (eg Cystic Fibrosis CFTR-~70% in
> Caucasians), but what about the other 30%, not to mention
> the other genes where mutations are spread more evenly.
> Surely sequencing is the way to go to get complete coverage?
> I did have to do a lot of manual searching elsewhere like
> the NCBI databases to find out what each SNP was about--is
> the information more accessible at 23andMe once you've paid
> your money and get the results back?
>
> Sorry about that first bit. I realise it's a bit off topic
> in a genealogy list. But in order to be able to browse raw
> results one has to get the Complete test not just the
> Ancestry part. Also I am wondering about the usefulness of
> getting Complete tests for my wife and 2 sons. Would it be
> possible to piece together chunks of the genome and sort out
> all our chromosomes?
>
> Nick
>
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