Archiver > GENEALOGY-DNA > 2010-03 > 1268888359

Subject: [DNA] New estimate for human mutation rate
Date: Wed, 17 Mar 2010 21:59:19 -0700

The following appeared in today's on-line version of Nature.

We are family

Science doi:10.1126/science.1186802 (2010)

The human mutation rate is lower than previously thought, according to researchers who sequenced the entire genomes of four family members - two siblings with rare

genetic disorders, and their parents. David Galas and Leroy Hood at the Institute for Systems Biology in Seattle, Washington, and their colleagues estimate that

roughly 70 new mutations arise per genome between generations. This is lower than earlier estimates based on genomic comparisons between humans and their

closest living relatives, chimpanzees. The team also pinpointed four genes likely to underlie the siblings' two disorders - Miller syndrome and primary ciliary

dyskinesia. The four genes are a subset of those reported in previous studies.

For a longer story on this research, see

Richard R. Kenyon ("Dick")

This thread: