GENEALOGY-DNA-L Archives

Archiver > GENEALOGY-DNA > 2010-03 > 1268920954


From: Al Aburto <>
Subject: Re: [DNA] New estimate for human mutation rate
Date: Thu, 18 Mar 2010 07:02:55 -0700
References: <835736.54425.qm@web24507.mail.ird.yahoo.com>
In-Reply-To: <835736.54425.qm@web24507.mail.ird.yahoo.com>


Fewer mutations indicates a slower mutation rate I think ==> at least Zhiv?

> On 3/18/2010 1:01 AM, Anders Pålsen wrote:
> So is it Zhiv or germline?
>
> Anders
>
> --- Den tor 2010-03-18 skrev RICHARD KENYON<>:
>
>
>> The following appeared in today's
>> on-line version of Nature.
>> GENOMICS
>>
>> We are family
>>
>> Science doi:10.1126/science.1186802 (2010)
>>
>> The human mutation rate is lower than previously thought,
>> according to researchers who sequenced the entire genomes of
>> four family members - two siblings with rare
>>
>> genetic disorders, and their parents. David Galas and Leroy
>> Hood at the Institute for Systems Biology in Seattle,
>> Washington, and their colleagues estimate that
>>
>> roughly 70 new mutations arise per genome between
>> generations. This is lower than earlier estimates based on
>> genomic comparisons between humans and their
>>
>> closest living relatives, chimpanzees. The team also
>> pinpointed four genes likely to underlie the siblings' two
>> disorders - Miller syndrome and primary ciliary
>>
>> dyskinesia. The four genes are a subset of those reported
>> in previous studies.
>>
>> For a longer story on this research, see
>> go.nature.com/Owe9CD
>>
>>
>> Richard R. Kenyon ("Dick")
>>
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