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From: David Faux <>
Subject: Re: [DNA] Article: Can a sex-biased human demography account forthe reduced effective population size of chromosome X innon-Africans?
Date: Sun, 16 May 2010 20:29:48 -0700
References: <AANLkTilnT_FjznsRYtexxFrfFyCXV4xIWCKc7A2GKV_p@mail.gmail.com>
In-Reply-To: <AANLkTilnT_FjznsRYtexxFrfFyCXV4xIWCKc7A2GKV_p@mail.gmail.com>


Access to original article:
http://keinanlab.cb.bscb.cornell.edu/Primarily_male_dispersal_out_of_Africa.pdf

David K. Faux.
On Sun, May 16, 2010 at 6:24 PM, steven perkins <> wrote:

> MBE Advance Access published online on May 7, 2010
> Molecular Biology and Evolution, doi:10.1093/molbev/msq117
>
> © The Author 2010. Published by Oxford University Press on behalf of
> the Society for Molecular Biology and Evolution. All rights reserved.
> For permissions, please e-mail:
>
>
> Research Article
>
> Can a sex-biased human demography account for the reduced effective
> population size of chromosome X in non-Africans?
> Alon Keinan1,* and David Reich2,3
>
> 1 Department of Biological Statistics and Computational Biology,
> Cornell University, Ithaca, NY
> 2 Department of Genetics, Harvard Medical School, Boston, MA
> 3 Broad Institute of Harvard and MIT, Cambridge, MA
>
> * To whom correspondence should be addressed (Department of Biological
> Statistics and Computational Biology, 102A Weill Hall, Cornell
> University, Ithaca, NY 14853; Tel: 607-254-1328, Fax: 607-255-4698 ;
> )
>
> Received for publication October 2, 2009. Revision received April 9,
> 2010. Accepted for publication May 3, 2010.
>
> Sex-biased demographic events can result in asymmetries in female and
> male effective population size that can lead to different patterns of
> genetic variation on chromosome X than are expected based on the
> patterns on the autosomes. Previous studies point to a period around
> the time of the dispersal of anatomically modern humans out of Africa
> when chromosome X experienced a significant reduction in effective
> population size relative to the autosomes. Here, we explore whether a
> sex-biased demographic history could explain these observations. We
> use coalescent simulations to show that a model of primarily male
> migration during the Out-of-Africa dispersal can produce the striking
> patterns that are observed when comparing patterns of genetic
> variation on the autosomes and chromosome X. The model involves a
> history in which after the founder population of non-Africans lost
> much of its genetic diversity, subsequent mostly-male gene flow from
> an African source brought new diversity into the population. We also
> explore two additional models, one of sex-biased generation time and
> one of a substructured population during the dispersal out of Africa
> with primarily female migration among demes. These latter models
> cannot account for the magnitude of the observed reduction in
> chromosome X effective population size, although it is plausible that
> they played a more minor role in producing the striking chromosome
> X/Autosome patterns.
>
> Key Words: gender-biased demography • chromosome X • autosomes •
> effective population size • coalescent simulations • human
> --
>
> Steven C. Perkins
> http://stevencperkins.com/
> Online Journal of Genetics and Genealogy
> http://jgg-online.blogspot.com/
> Steven C. Perkins' Genealogy Page
> http://stevencperkins.com/genealogy.html
> Steven C. Perkins' Genealogy Blog
> http://scpgen.blogspot.com/
>
>
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