GENEALOGY-DNA-L Archives

From: steven perkins <>
Subject: [DNA] Article: Identification of population substructure among Jewsusing STR markers and dependence on reference populations included
Date: Sat, 28 Aug 2010 10:20:51 -0400

I don't believe this recent article using autosomal markers has been discussed:
=========================
Full test available:
http://www.biomedcentral.com/1471-2156/11/48/abstract/

Identification of population substructure among Jews using STR markers
and dependence on reference populations included

Jennifer B Listman 1 email, Deborah Hasin3,7,8 email, Henry R
Kranzler4 email, Robert T Malison1,2 email, Apiwat Mutirangura5 email,
Atapol Sughondhabirom5 email, Efrat Aharonovich3 email, Baruch Spivak6
email and Joel Gelernter1,2,9,10 email

1 Department of Psychiatry, Yale University School of Medicine, New
Haven, CT, USA
2 VA Connecticut Healthcare System, West Haven Campus, West Haven, CT, USA
3 Department of Psychiatry, Columbia University College of Physicians
and Surgeons, NY, USA
4 Departments of Psychiatry and Genetics and Developmental Biology,
University of Connecticut School of Medicine, Farmington, CT, USA
5 Chulalongkorn Faculty of Medicine, Bangkok, Thailand
6 Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
7 New York State Psychiatric Institute, NY, USA
8 Dept Epidemiology, Mailman School of Public Health, Columbia
University, NY, USA
9 Department of Genetics, Yale University School of Medicine, New
Haven, CT, USA
10 Department of Neurobiology, Yale University School of Medicine,
New Haven, CT, USA

author email corresponding author email

BMC Genetics 2010, 11:48doi:10.1186/1471-2156-11-48
Published: 14 June 2010

Abstract

Background

Detecting population substructure is a critical issue for association
studies of health behaviors and other traits. Whether inherent in the
population or an artifact of marker choice, determining aspects of a
population's genetic history as potential sources of substructure can
aid in design of future genetic studies. Jewish populations, among
which association studies are often conducted, have a known history of
migrations. As a necessary step in understanding population structure
to conduct valid association studies of health behaviors among Israeli
Jews, we investigated genetic signatures of this history and
quantified substructure to facilitate future investigations of these
phenotypes in this population.

Results

Using 32 autosomal STR markers and the program STRUCTURE, we
differentiated between Ashkenazi (AJ, N = 135) and non-Ashkenazi (NAJ,
N = 226) Jewish populations in the form of Northern and Southern
geographic genetic components (AJ north 73%, south 23%, NAJ north 33%,
south 60%). The ability to detect substructure within these closely
related populations using a small STR panel was contingent on
including additional samples representing major continental
populations in the analyses.

Conclusions

Although clustering programs such as STRUCTURE are designed to assign
proportions of ancestry to individuals without reference population
information, when Jewish samples were analyzed in the absence of proxy
parental populations, substructure within Jews was not detected.
Generally, for samples with a given grandparental country of birth,
STRUCTURE assignment values to Northern, Southern, African and Asian
clusters agreed with mitochondrial DNA and Y-chromosomal data from
previous studies as well as historical records of migration and
intermarriage.

--
Steven C. Perkins      
http://stevencperkins.com/
Online Journal of Genetics and Genealogy
http://jgg-online.blogspot.com/
Steven C. Perkins' Genealogy Page
http://stevencperkins.com/genealogy.html
Steven C. Perkins' Genealogy Blog
http://scpgen.blogspot.com/

This thread:

• [DNA] Article: Identification of population substructure among Jewsusing STR markers and dependence on reference populations included by steven perkins <>