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Archiver > GENEALOGY-DNA > 2010-11 > 1290101082


From: Vince Tilroe <>
Subject: Re: [DNA] Age of Zhong et al. (2010) R1b-related lineages
Date: Thu, 18 Nov 2010 10:24:42 -0700
References: <mailman.3634.1290060227.2059.genealogy-dna@rootsweb.com><1359FAAFAC5C42F38A99E4D6291DE638@anatoldesktop><10B25788-DE27-467D-BC6F-3E32D5203690@vizachero.com><4CE55E28.9090709@scs.uiuc.edu>
In-Reply-To: <4CE55E28.9090709@scs.uiuc.edu>


This is an interesting approach for handling recLOH.

Can you apply this technique it to include additional markers to represent
SNPs, say ancestral as 1 and derived as 2, and presume a per locus mutation
rate of 0.0001 or something suitably slow?

Vince T.

On 18 November 2010 10:11, Doug McDonald <> wrote:

> What you SHOULD do in such cases is as follows.
>
> You should change the number for DYS390 by the amount of the deletion,
> so it would be as if the deletion had not occurred. Then you add another
> marker to you set (making 67 go to 68, for example), and you recalculate
> the average rate by multiplying the normal average rate by 67/68.
>
> You also add a new marker to your table of makers, say call it 390-DEL.
> You choose a number for the normal people, say 2. For the deleted
> people you use 1. Then proceed as normal.
>
> This is also the way to do rec-LOHs.
>
> Doug McDonald
>
>


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