GENEALOGY-DNA-L ArchivesArchiver > GENEALOGY-DNA > 2010-11 > 1290101082
From: Vince Tilroe <>
Subject: Re: [DNA] Age of Zhong et al. (2010) R1b-related lineages
Date: Thu, 18 Nov 2010 10:24:42 -0700
This is an interesting approach for handling recLOH.
Can you apply this technique it to include additional markers to represent
SNPs, say ancestral as 1 and derived as 2, and presume a per locus mutation
rate of 0.0001 or something suitably slow?
On 18 November 2010 10:11, Doug McDonald <> wrote:
> What you SHOULD do in such cases is as follows.
> You should change the number for DYS390 by the amount of the deletion,
> so it would be as if the deletion had not occurred. Then you add another
> marker to you set (making 67 go to 68, for example), and you recalculate
> the average rate by multiplying the normal average rate by 67/68.
> You also add a new marker to your table of makers, say call it 390-DEL.
> You choose a number for the normal people, say 2. For the deleted
> people you use 1. Then proceed as normal.
> This is also the way to do rec-LOHs.
> Doug McDonald
|Re: [DNA] Age of Zhong et al. (2010) R1b-related lineages by Vince Tilroe <>|