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Archiver > GENEALOGY-DNA > 2011-01 > 1295505791


From: "Tim Janzen" <>
Subject: Re: [DNA] WTY
Date: Wed, 19 Jan 2011 22:43:11 -0800
In-Reply-To: <017301cbb819$cbbcc3b0$c2482dae@Ken1>


Dear All,
I think that we should also start thinking about the possibility of
complete genome sequencing in terms of finding new Y SNPs. I have recently
been contacting some companies I am familiar with to see what their current
prices for complete genome sequencing are. The best price I have seen thus
far is from Complete Genomics. They quoted me a price that is 12.67 times
the current price of WTY per complete sequence if one were to order at least
8 complete sequences. They quote an accuracy rate of 99.999% (see
http://www.completegenomics.com/services/complete-sequencing). Thus, if
they were sequencing approximately 25 million base pairs on the Y we would
expect that there would be approximately 250 false positive SNPs that would
be reported. Thus, if this approach were to be undertaken it would make
sense to have two closely related males tested. One would then review the
SNPs that Complete Genomics reported for each of these two people, but only
utilize the SNPs for which both people were positive. It might make sense
for the people in the larger subclades to think about pooling their
resources to order at least two complete genomes for closely related people
in their subclade and to coordinate with others to come up with an order for
8 complete sequences.
Sincerely,
Tim Janzen

-----Original Message-----
From:
[mailto:] On Behalf Of Ken Nordtvedt
Sent: Wednesday, January 19, 2011 12:45 PM
To:
Subject: Re: [DNA] WTY

That probably depends on your haplogroup and clade membership within the
haplogroup and whether others from it have tested. And ultimately, the
worth is best measured by factors unique to the person or persons paying the

freight.

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