GENEALOGY-DNA-L ArchivesArchiver > GENEALOGY-DNA > 2011-02 > 1297648521
From: steven perkins <>
Subject: [DNA] Article: Mitochondrial DNA structure in North Africa revealsa genetic discontinuity in the Nile Valley.
Date: Sun, 13 Feb 2011 20:55:21 -0500
Am J Phys Anthropol. 2011 Feb 10. doi: 10.1002/ajpa.21472. [Epub ahead of print]
Mitochondrial DNA structure in North Africa reveals a genetic
discontinuity in the Nile Valley.
Fadhlaoui-Zid K, Rodríguez-Botigué L, Naoui N, Benammar-Elgaaied A,
Calafell F, Comas D.
Laboratory of Genetics, Immunology, and Human Pathology, Faculty of
Science of Tunis, University Tunis El Manar, 2092 Tunis, Tunisia.
Human population movements in North Africa have been mostly restricted
to an east-west direction due to the geographical barriers imposed by
the Sahara Desert and the Mediterranean Sea. Although these barriers
have not completely impeded human migrations, genetic studies have
shown that an east-west genetic gradient exists. However, the lack of
genetic information of certain geographical areas and the focus of
some studies in parts of the North African landscape have limited the
global view of the genetic pool of North African populations. To
provide a global view of the North African genetic landscape and
population structure, we have analyzed ∼2,300 North African
mitochondrial DNA lineages (including 269 new sequences from Libya, in
the first mtDNA study of the general Libyan population).
Our results show a clinal distribution of certain haplogroups, some of
them more frequent in Western (H, HV0, L1b, L3b, U6) or Eastern
populations (L0a, R0a, N1b, I, J) that might be the result of human
migrations from the Middle East, sub-Saharan Africa, and Europe.
Despite this clinal pattern, a genetic discontinuity is found in the
Libyan/Egyptian border, suggesting a differential gene flow in the
Nile River Valley. Finally, frequency of the post-LGM subclades H1 and
H3 is predominant in Libya within the H sequences, highlighting the
magnitude of the LGM expansion in North Africa.
Am J Phys Anthropol, 2011. © 2011 Wiley-Liss, Inc.
Copyright © 2011 Wiley-Liss, Inc.
PMID: 21312180 [PubMed - as supplied by publisher]
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Steven C. Perkins
Online Journal of Genetics and Genealogy
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