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Archiver > GENEALOGY-DNA > 2011-07 > 1310220203


From: Ann Turner <>
Subject: Re: [DNA] Markers that determine someone is Irish and Scottish
Date: Sat, 9 Jul 2011 07:03:23 -0700
References: <CANvDYaVeq4nyog2+YsdgP0bGooczJj8yi1v5yzn0mpYbMz5HsA@mail.gmail.com><009201cc3e05$4c0d2430$e4276c90$@com><CANvDYaXP4wgGRRhjC=B+CbmAj4F4Tb2PSjJhm1_VGgiqFsDuBA@mail.gmail.com><00aa01cc3e13$d3996d10$7acc4730$@com><CANvDYaURXEDUGV+xh0t8_gcgWoLzT7J7N0yLOd7DwreVEFhM-w@mail.gmail.com>
In-Reply-To: <CANvDYaURXEDUGV+xh0t8_gcgWoLzT7J7N0yLOd7DwreVEFhM-w@mail.gmail.com>


The full text of the technical article about the complete genome sequence of
this Irishman is available online.

http://genomebiology.com/2010/11/9/R91

His sample was specifically selected as being typical for an Irishman from a
previous study using a genome wide scan. It was based on an Illumina chip
with about 500,000 markers, similar to the one used by 23andMe and by FTDNA
for Family Finder / Population Finder. Figure S1 is a PC (Principle
Components) diagram, a way of showing how similar or different various
samples are. This dataset is not available to FTDNA or 23andMe.

The same article states that his Y-DNA tested positive for a SNP called S145
( L21 at FTDNA). There is a Y-DNA signature that is commonly (but not
exclusively) found in Irish, which FTDNA calls "Niall of the Nine Hostages."
It is positive for a SNP called M222, a subclade of L21. The sample in the
above paper was negative for that.

http://www.familytreedna.com/landing/matching-niall.aspx

Genetic genealogists continue to look for clusters of similar Y-STR results,
so you may see terms like "Irish Type III."

Ann


On Sat, Jul 9, 2011 at 2:17 AM, Karen Hodges <> wrote:

> Hi Bob
>
> Thanks for explaining. I am trying to read as much as I can about the
> subject of DNA testing. Each time I think I understand I find another
> piece
> which makes me reassess what I thought the last was saying.
>
> When they say "showed variation typical of the island"" does that mean
> that this man who is consider Irish [due to being a 3rd generation]
> matched
> what they have found to date for people being tested who live in the
> country
> [who they did not know how Irish these past testers were]?
>
> What is PF please?
>
> Karen
>
>
> On Sat, Jul 9, 2011 at 6:40 PM, Bob May <> wrote:
>
> > Karen
> > Yes you did get it bit mixed.
> > What they are talking about is sequencing the whole genome of an Irish
> > person. These are SNPs for the purpose of your enquiry and not STRs which
> > is
> > what is measured with YDNA test.
> > Note this remark " the individual chosen was considered a good example of
> > Irish DNA and "showed variation typical of the island""
> > This would not even be classed as identifying "Irish" as such - it is
> only
> > one person.
> > Remember that in PF they classify the UK as one "population" based on the
> > results from the Orkney Islands, which is an isolated population and has
> at
> > least 4 generations born on the island.
> > Bob
> >
> >
> > -----Original Message-----
> > From:
> > [mailto:] On Behalf Of Karen Hodges
> > Sent: Saturday, July 09, 2011 6:03 PM
> > To:
> > Subject: Re: [DNA] Markers that determine someone is Irish and Scottish
> >
> > Hi Bob
> >
> > I could be confused about what is being spoken about. I found this
> article
> > from September 2010
> >
> >
> http://www.irishcentral.com/news/Irish-DNA-isolated-for-first-time-ever--102
> > 330169.html
> >
> > Karen
> >
> > A single marker would not indicate this.
> >
> > > I am not aware of any haplotype that specifically would identify anyone
> > as
> > > being of a single race. A haplotype may indicate a high probability
> that
> > a
> > > person could be of that race, but not that they are.
> > > Bob
> > >
> > >
> >
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