GENEALOGY-DNA-L ArchivesArchiver > GENEALOGY-DNA > 2011-11 > 1320611288
From: RThrift <>
Subject: Re: [DNA] Any feedback on the RCC method of TMRCA estimates?
Date: Sun, 6 Nov 2011 12:28:08 -0800
Sandy, please do, that's the point here.
FYI, part 2 of Howard's pair of papers is at
Ken, just read it (part 1).
Once a matrix of pairwise correlation coefficients is set up (some details seem to be obscured in the paper), as Sandy mentioned each value is scaled: Take the reciprocal of the 'correlation coefficient' so calculated. Subtract 1. Multiply by 10,000. =RCC
But that's just the starting point. He in effect comes up with an overall mutation rate ("time scale") from known pedigree /haplotype data using the Hodges-Lehmann estimator and pairwise TMRCAs. 1 RCC = 43.3 years, SD ~ 8%.
He argues that the average RCC of a cluster is a good proxy for the MRCA of the cluster. Time to the common ancestor = 52.7 x (the average RCC of the cluster) (just read the paper!)
From: "Sandy Paterson" <alexanderpatterson@
...I could also easily show how the paper uses (abuses?) the concept in trying to apply it to two haplotypes.
|Re: [DNA] Any feedback on the RCC method of TMRCA estimates? by RThrift <>|