GENEALOGY-DNA-L ArchivesArchiver > GENEALOGY-DNA > 2012-01 > 1328020612
From: Bill <>
Subject: Re: [DNA] Question regarding Markers DYS459 and DYS464
Date: Tue, 31 Jan 2012 09:36:52 -0500
Multi step mutations could be the result of either RecLOH mutations,
or of several single point mutations occuring in different ancestors.
I've noticed that multistep mutations are rarely found when there is
only a single marker that has changed, and the frequency of multistep
mutations increases as the total number of changed markers increases.
Does that imply that most multistep mutations are due to a series of
single point mutations, and that RecLOH's are relatively uncommon?
FTDNA makes adjustments in the calculation of genetic distance based
on the rates at which different markers mutate. If RecLOH's are
easily recognized, I'd think they'd account for this as well. Do they?
On Jan 29, 2012, at 1:21 PM, Kenneth Nordtvedt wrote:
> Your new member's ancestral branch line had a so-called recLOH
> event which simultaneosly doubled up the repeat values for DYS459,
> and probably CDY.
> That is a single mutation event. It is not a genetic distance of