GENEALOGY-DNA-L Archives

Archiver > GENEALOGY-DNA > 2012-02 > 1330044951


From: Richard Stevens <>
Subject: Re: [DNA] Family Finder, Lactase Persistence, and rs4988235
Date: Thu, 23 Feb 2012 19:55:51 -0500
References: <CANZ0abK+S=gjnkaAjpTvYXCWecn7p8nNRB8tVdqjHr_Zu3YR-Q@mail.gmail.com>
In-Reply-To: <CANZ0abK+S=gjnkaAjpTvYXCWecn7p8nNRB8tVdqjHr_Zu3YR-Q@mail.gmail.com>


I just found out there is second SNP associated with lactase
persistence/lactose intolerance in Europeans, rs182549, and it too is
included in FTDNA's Family Finder test. At rs182549, a "CT" or "TT"
indicates probable lactase persistence. A "CC" indicates probable lactose
intolerance.

I have a "TT" at rs182549, so I am lactase persistent on that indicator, as
well.

But what is 13910, and how does it differ from rs4988235 and rs182549?

Rich

On Thu, Feb 23, 2012 at 7:23 PM, Richard Stevens <>wrote:

> This past weekend I discovered that FTDNA's Family Finder test includes *
> rs4988235*, which is the SNP associated with lactase persistence in
> Europeans. Once I downloaded 7-zip (which is free, btw) and figured out how
> to unzip my raw autosomal data, I discovered I have "AA" at rs4988235,
> which indicates that I am lactase persistent, something I knew already from
> personal experience. Just the same, it was interesting to see the dna
> evidence supporting my experience and to learn that I inherited that trait
> from both of my parents. An "AG" or an "AA" at rs4988235 indicates probable
> lactase persistence. A "GG" there means one is probably lactose intolerant.
>
> When I have read reports about lactase persistence in the past, they have
> always referred to 13910 as the "lactase persistence" allele, with results
> of "CT" and "TT" indicating lactase persistence and "CC" indicating lactose
> intolerance.
>
> So, what is the difference between 13910 and rs4988235?
>
> Thanks in advance for the explanation.
>
> Rich
>

This thread: